Endocrine Abstracts

Introduction: Ovarian adrenal rest tumors (OARTs), in contrast with testicular adrenal rest tumors, are very rare. Up to date, 13 cases were reported in the literature; all treated surgically.Aim: We describe a case of a young female with uncontrolled classical congenital adrenal hyperplasia (CCAH), presenting with bilateral OARTs, successfully treated with steroid replacement.Methods: Data on clinical history and biochemical work-...

Background: The prevalence of adrenal incidentalomas has increased. The malignancy is determined by radiographic appearance and, secondly, by the size. Adenomas manifest a low attenuation on computed tomography (CT) (<10 Hounsfield Units(HU)).The cut-off point of 10 HU has been proposed to discriminate benign and malignant lesions.Objective: To determine if the cut-off point of 10 HU is useful in clinical practice to discriminate benign and malignant...

Introduction: Graves’ ophthalmopathy (GO) is an autoimmune disorder that constitutes a major clinical and therapeutic challenge. Current treatment options for moderate-to-severe GO include immunotherapy, orbital radiotherapy and decompression surgery. Limited drugs of proven efficacy are available for the treatment of people with GO. Given the role in the pathogenesis of GO of interleukin (IL)-6 expression in adipocytes, fibroblasts and macrophages, the proposed theory i...

Introduction: Cushing’s disease (CD) is a potentially fatal disease caused by corticotrophic adenoma of the pituitary gland. Crooke Cell Adenomas (CCA) are a rare variant characterized by cytoplasmic ring deposits of cytokeratin filaments. They are usually aggressive macroadenomas with a higher rate of recurrence and malignancy.Clinical case: A 36 year old man, with 34 kg weight gain and uncontrolled hypertension for 4 years presented at the Emerge...

Introduction: The Quervain’s disease is an infrequent subacute thyroiditis (ST) that results in granulomatous infiltration of the gland’s parenchyma. Is usually diagnosed clinically based on cervical pain, systemic symptoms, altered thyroid function tests (TFTs) and history of upper respiratory tract infection. It is a benign self-limited condition that may share US features with malignancy which may result in improper therapy, including lobectomy.<p class="abs...

Introduction: Lithium therapy is commonly used in bipolar disorder treatment. Alongside the increasing prevalence of goiter and hypothyroidism, the sustaining use of lithium therapy is associated with several metabolic disorders, such as hypercalcemia and hyperparathyroidism (HPT).Case report: A 64-year-old woman with history of bipolar disorder treated with lithium for several years was referred to our department for evaluation of recurrent hypercalcemi...

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

Background: HIV-infected paediatric patients usually show impaired growth. Data reporting abnormalities in GH–IGF–IGFBPs system are scarce and inconclusive.Aim: To analyse blood concentration of the major components of IGF–IGFBPs system in these children and compare them to growth parameters and to cytokines levels.Methods: prepubertal HIV-infected children, aged 8.2±1.7 years, were evaluated every 6 months duri...

Introduction: Thyroid surgery is nowadays associated with low morbidity and extremely low mortality. A consistent association has been observed between high surgical volume and better outcomes. Patients who undergo surgery by a skilled surgeon have fewer complications. On the other hand, different surgical techniques have been associated with different outcomes. Since 1997, thyroid diseases are treated in our department by a multidisciplinary team.Object...